Ketamine for Pain, Opioid Use, and Mental Health in Orthopedic Trauma
Phase 4 trial of ketamine during orthopedic trauma surgery to reduce pain, opioid use, and post-injury depression and PTSD.
This is an interventional study — the research team administers the treatment under a controlled, IRB-approved protocol. Participation never happens outside that protocol.
- Substance
- Ketamine
- Status
- Recruiting now
- Conditions
- PTSD, Depression, Substance use
- Who can join
- Trauma surgery patients 18–65
- Where
- Lubbock, TX
- Run by
- Texas Tech University Health Sciences Center
- Registry ID
- NCT06903819 ↗
How to join this study
Call or email the study team directly. You do not go through Psychedelic Vets — we just make the door easier to find.
Contact details as published by the sponsor, last verified 2026-03. People move on — if this doesn't reach anyone, check ClinicalTrials.gov.
What taking part involves
Participants in this group will receive a single intraoperative dose of intravenous (IV) ketamine (0.5 mg/kg) within 30 minutes of anesthesia induction. The intervention is designed to assess ketamine's effects on postoperative pain, opioid use, and symptoms of depression and PTSD in patients undergoing surgical fixation for musculoskeletal trauma.
Participants in this group will receive standard general anesthesia without ketamine. This group serves as a comparison to evaluate the effectiveness of ketamine on postoperative pain levels, opioid consumption, and psychological recovery following orthopedic trauma surgery.
Who can join
Listed as the research team wrote them. This is not a decision about you — only the study team can say whether you are eligible, and the only way to find out is to ask them.
What the study is looking for
- Adults aged 18-65
- Undergoing acute operative fixation for musculoskeletal trauma
- Injury Severity Score (ISS) greater than 15
- Ability to provide informed consent (or consent provided by a legally authorized representative)
What would rule you out
- Age under 18 or over 65
- Use of ketamine for preoperative or postoperative sedation
- Known allergy or contraindication to ketamine
- Prior unsuccessful ketamine therapy for major depressive disorder (MDD) or PTSD
- Severe psychiatric conditions or psychotic features
- History of dementia or glaucoma
- Currently engaged in trauma-focused cognitive behavioral therapy or PTSD psychotherapy started within the past 3 months
You enroll directly with the research team through their own official page and IRB-approved consent process. Psychedelic Vets does not run this study or collect any of your health information.
Study data is sourced from ClinicalTrials.gov (U.S. National Library of Medicine) and verified university/nonprofit sources. This page is educational and is not medical advice or an endorsement. Details can change — always confirm on the official page above. ← Back to all studies
