Dose Optimization of MDMA-Assisted Therapy for PTSD
VA study finding the optimal number of MDMA-assisted therapy cycles for veterans with PTSD.
This is an interventional study — the research team administers the treatment under a controlled, IRB-approved protocol. Participation never happens outside that protocol.
- Substance
- MDMA
- Status
- Recruiting now
- Conditions
- PTSD
- Who can join
- Veterans only
- Where
- Bronx, NY
- Run by
- James J. Peters / Bronx VA
- Registry ID
- NCT06418178 ↗
How to join this study
Call or email the study team directly. You do not go through Psychedelic Vets — we just make the door easier to find.
Contact details as published by the sponsor, last verified 2025-06. People move on — if this doesn't reach anyone, check ClinicalTrials.gov.
What taking part involves
Open label, within-subjects treatment arm. Participants receive 120mg + optional 60mg supplement. There will be from one to five dosing sessions that occur three to five weeks apart. Each dosing session is followed by three integration psychotherapy sessions.
Who can join
Listed as the research team wrote them. This is not a decision about you — only the study team can say whether you are eligible, and the only way to find out is to ask them.
What the study is looking for
- 1. Are a U.S. military veteran at least 18 years old.
- 2. Are able to provide written, informed consent.
- 3. Are able to swallow pills.
- 4. Agree to have study visits recorded, including Experimental Sessions, psychological assessments, and non-drug therapy sessions.
- 5. Must provide a contact who is willing and able to be reached by the investigators in the event of a participant becoming unwell or unreachable.
- 6. If able to become pregnant, must have a negative pregnancy test at study entry and prior to each Experimental Session, and must agree to use adequate contraceptive methods.
- 7. Must have a current PTSD diagnosis at screening and baseline.
- 8. Must not participate in any other interventional clinical trials for the duration of the study.
- 9. Must commit to medication dosing, therapy, and all study procedures.
What would rule you out
- 1. Are not able to give adequate informed consent.
- 2. Have a history of any medical condition, or any significant clinical finding on screening tests, that could make receiving a sympathomimetic drug harmful.
- 3. Have uncontrolled hypertension.
- 4. Have evidence or history of significant medical or psychiatric disorders.
- 5. Have symptomatic liver disease.
- 6. Have history of hyponatremia or hyperthermia.
- 7. Weigh less than 48 kilograms (kg).
- 8. Unable or unwilling to safely taper off prohibited psychiatric medication.
- 9. Abusing illegal drugs or alcohol.
- 10. Have received Electroconvulsive Therapy (ECT) or ketamine therapy within 12 weeks of enrollment.
- 11. Are pregnant or nursing or are able to become pregnant and are not practicing an effective means of contraception.
You enroll directly with the research team through their own official page and IRB-approved consent process. Psychedelic Vets does not run this study or collect any of your health information.
Study data is sourced from ClinicalTrials.gov (U.S. National Library of Medicine) and verified university/nonprofit sources. This page is educational and is not medical advice or an endorsement. Details can change — always confirm on the official page above. ← Back to all studies
