Ketamine in Severe Traumatic Brain Injury
Early-phase trial of ketamine in patients hospitalized with severe traumatic brain injury.
This is an interventional study — the research team administers the treatment under a controlled, IRB-approved protocol. Participation never happens outside that protocol.
- Substance
- Ketamine
- Status
- Recruiting now
- Conditions
- TBI
- Who can join
- Adults 18+ with severe TBI
- Where
- Dallas, TX
- Run by
- UT Southwestern Medical Center
- Registry ID
- NCT06062628 ↗
How to join this study
Call or email the study team directly. You do not go through Psychedelic Vets — we just make the door easier to find.
Contact details as published by the sponsor, last verified 2026-01. People move on — if this doesn't reach anyone, check ClinicalTrials.gov.
What taking part involves
A single dose of 0.5 mg/kg (actual body weight) of ketamine will be administered intravenously. Ketamine will be administered in addition to the patient's existing analgesia, sedation and other medicines as a part of their routine treatment.
Who can join
Listed as the research team wrote them. This is not a decision about you — only the study team can say whether you are eligible, and the only way to find out is to ask them.
What the study is looking for
- Severe traumatic brain injury
- Placement of intracranial monitor for measurement of intracranial pressure and brain tissue oxygenation
- Age greater than or equal to 18 years
What would rule you out
- Documented allergy to ketamine
- Sinus tachycardia with sustained heart rate \>120
- Any episode of non-sinus tachycardia
- Documented history of schizophrenia
- Systolic blood pressure \> 180, diastolic blood pressure \> 120
- Documented episode(s) of ICP elevations \>25 mm Hg sustained greater than 5 minutes within 24 hours
- Similar episodes as above of PbtO2 \<15 mmHg
- Positive pregnancy test and/or is currently breast-feeding
You enroll directly with the research team through their own official page and IRB-approved consent process. Psychedelic Vets does not run this study or collect any of your health information.
Study data is sourced from ClinicalTrials.gov (U.S. National Library of Medicine) and verified university/nonprofit sources. This page is educational and is not medical advice or an endorsement. Details can change — always confirm on the official page above. ← Back to all studies