MDMA-Assisted Therapy for Moderate to Severe PTSD
MDMA-assisted therapy for veterans with moderate-to-severe PTSD.
This is an interventional study — the research team administers the treatment under a controlled, IRB-approved protocol. Participation never happens outside that protocol.
- Substance
- MDMA
- Status
- Recruiting now
- Conditions
- PTSD
- Who can join
- Veterans only
- Where
- California
- Run by
- VA Greater LA / UCLA (S. Marder)
- Registry ID
- NCT05790239 ↗
How to join this study
Call or email the study team directly. You do not go through Psychedelic Vets — we just make the door easier to find.
Contact details as published by the sponsor, last verified 2025-03. People move on — if this doesn't reach anyone, check ClinicalTrials.gov.
What taking part involves
Participants will receive a flexible divided-dose of MDMA plus therapy at Experimental Sessions.
Participants will receive a flexible divided dose plus therapy at Experimental Sessions.
Who can join
Listed as the research team wrote them. This is not a decision about you — only the study team can say whether you are eligible, and the only way to find out is to ask them.
What the study is looking for
- At Screening, meet DSM-5 criteria for current PTSD with a symptom duration of at least 6 months.
- Fluent in speaking and reading the predominantly used or recognized language of the study site (English).
- Must be a veteran enrolled at a VA Healthcare Center in the Greater Los Angeles area.
- Able to swallow pills.
- Agree to have study visits audiovisually recorded, including Experimental Sessions, IR assessments, and non-drug therapy sessions.
- Able to provide a contact (relative, spouse, close friend, or other support person) who is willing and able to be reached by the investigators in the event of the participant becoming unwell or unreachable.
- Able to identify appropriate support person(s) to stay with the participant on the evenings of Experimental Sessions if needed.
- May have well-controlled hypertension that has been successfully treated with anti-hypertensive medicines, if they pass additional screening to rule out underlying cardiovascular disease.
- May have asymptomatic Hepatitis C virus (HCV) that has previously undergone evaluation and treatment as needed.
- Body weight of at least 45 kilograms (kg). Participants with a body weight of 45-48 kg must also have a body mass index (BMI) within the range of 18 to 30 kg/m2. BMI must be within 18 to 32 kg/m2 (inclusive).
- A person able to be pregnant (PABP) must use a highly effective contraceptive method.
What would rule you out
- Are not able to give adequate informed consent.
- Have evidence or history of significant medical or psychiatric disorders.
- Are abusing illegal drugs.
- Unable or unwilling to safely taper off prohibited psychiatric medication.
- Current enrollment in any other clinical study involving an investigational study treatment or any other type of medical research, unless approved by the study clinician.
You enroll directly with the research team through their own official page and IRB-approved consent process. Psychedelic Vets does not run this study or collect any of your health information.
Study data is sourced from ClinicalTrials.gov (U.S. National Library of Medicine) and verified university/nonprofit sources. This page is educational and is not medical advice or an endorsement. Details can change — always confirm on the official page above. ← Back to all studies
