Ibogaine–Magnesium Therapy for Veterans With Blast TBI
Observational Stanford study following veterans with repeated blast/combat head trauma before and after ibogaine–magnesium therapy. Findings were published in Nature Medicine (2024). Underway — closed to new enrollment.
This study is already underway and closed to new participants. It's listed here so you can see the research happening in the field right now.
This is an observational study — researchers document or measure participants' experiences and outcomes. It does not provide any substance.
- Substance
- Ibogaine
- Status
- In progress
- Conditions
- TBI
- Who can join
- U.S. veterans (18–70) with combat/blast head trauma
- Where
- Stanford, CA
- Run by
- Stanford University (N. Williams)
- Registry ID
- NCT04313712 ↗
How to join this study
The sponsor has not published a contact for this study. The official registry page is the only way in — it is updated by the research team and may list a contact later.
Open the study on ClinicalTrials.gov →What taking part involves
All study participants will be observed before and after they receive ibogaine-magnesium therapy.
Who can join
Listed as the research team wrote them. This is not a decision about you — only the study team can say whether you are eligible, and the only way to find out is to ask them.
What the study is looking for
- 1. Male or female veteran, 18 to 70 years of age, inclusive, at screen.
- 2. Able to read, understand, and provide written, dated informed consent prior to screening. Participants will be deemed likely to comply with the study protocol and communicate with study personnel about adverse events and other clinically important information.
- 3. Has a history of head trauma, combat or blast exposure.
- 4. Scheduled themselves for ibogaine-magnesium therapy at Nouvelle Vie in Mexico.
- 5. Participants must be willing and able to travel to Stanford University before and after ibogaine-magnesium therapy.
- 6. Capable of getting an MRI scan.
- 7. Willing to be video recorded during the consenting process. (to be stored on a secure server, no PHI associated with video recordings)
- 8. Body mass index between 17-35kg/m2.
- 9. If female, a status of non-childbearing potential or use of an acceptable form of birth control per the following specific criteria:
- 1. Non-childbearing potential (e.g., physiologically incapable of becoming pregnant, i.e., permanently sterilized (status post hysterectomy, bilateral tubal ligation), or is post-menopausal with her last menses at least one year prior to screening); or
- i. Childbearing potential, including women using any form of hormonal birth control, on hormone replacement therapy started prior to 12 months of amenorrhea, using an intrauterine device (IUD), having a monogamous relationship with a partner who has had a vasectomy, or is sexually abstinent.
- ii. Negative urinary pregnancy test at screening, confirmed by a negative urinary pregnancy test at randomization prior to receiving study treatment.
- iii. Willing and able to continuously use one of the following methods of birth control during the course of the study, defined as those which result in a low failure rate (i.e., less than 1% per year) when used consistently and correctly: implants, injectable or patch hormonal contraception, oral contraceptives, IUD, double-barrier contraception, sexual abstinence. The form of birth control will be documented at screening and baseline.
- 10. Participants must be US citizens.
What would rule you out
- 1. Female of childbearing potential who is not willing to use one of the specified forms of birth control during the study.
- 2. Female that is pregnant or breastfeeding.
- 3. Claustrophobic.
- 4. History of a neurological disorder (i.e. Parkinson's, epilepsy, dementia, etc.) excluding sequelae of traumatic injury.
- 5. In the judgment of the investigator, the subject is at significant risk for suicidal behavior during the course of their participation in the study.
- 6. History of schizophrenia or schizoaffective disorders, or any history of psychotic symptoms.
- 7. Has a clinically significant abnormality on the screening physical examination that might affect safety, study participation, or confound interpretation of study results.
- 8. Participation in any clinical trial with an investigational drug or device within the past month or concurrent to study participation.
- 9. Any current or past history of any physical condition which in the investigator's opinion might put the subject at risk or interfere with study results interpretation.
- 10. Any history of cardiovascular problems.
- 11. Any history of liver or kidney problems.
You enroll directly with the research team through their own official page and IRB-approved consent process. Psychedelic Vets does not run this study or collect any of your health information.
Study data is sourced from ClinicalTrials.gov (U.S. National Library of Medicine) and verified university/nonprofit sources. This page is educational and is not medical advice or an endorsement. Details can change — always confirm on the official page above. ← Back to all studies
